Amyloid

Amyloid Beta Protein

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Major description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current contained in the vascular amyloid deposits. Aβ40 includes of C-terminal membrane insertion area. It shows structural transition from random coil to a α-helical constructing in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen contained in the hippocampus, neocortex, and amygdala of victims with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation based mostly ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • contained in the temperature based mostly conformational evaluation utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) evaluation
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a facet of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

 

amyloid
amyloid

Reconstitution

For maximal pure prepare, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Utterly completely different Notes

Lyophilized from 0.1% TFA in H2O

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology contained in the human ideas and the diploma of scientific dementia. Current advances in our understanding of the event of amyloid pathology have helped remedy this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in fairly a number of swimming swimming swimming pools, can be additional fastidiously associated to illness state.

The composition of those swimming swimming swimming pools of Aβ exhibits totally fully completely different populations of amyloid deposits, and has express correlates with the scientific standing of the affected person. Imaging utilized sciences, together with new amyloid imaging brokers based totally completely on the chemical constructing of histologic dyes, in the mean time are making it doable to trace amyloid pathology together with illness enchancment contained in the residing affected particular person. Curiously, these approaches degree out that the Aβ deposited in AD is completely fully completely different from that present in animal fashions.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Amyloid Beta Protein

SPR-487C 100 µg x2
EUR 611
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-487E 100 µg x5
EUR 1240
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-488B 100 µg
EUR 617
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488C 100 µg x2
EUR 988
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488E 100 µg x5
EUR 1998
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-492B 100 µg
EUR 432

Amyloid Beta Protein

SPR-492C 100 µg x2
EUR 691
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-492E 100 µg x5
EUR 1405
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid beta A4 protein

AP78722 1mg
EUR 2640

Amyloid beta A4 protein

AP79877 1mg
EUR 2640

Amyloid beta A4 protein

AP80103 1mg
EUR 2640

Amyloid beta A4 protein

AP80119 1mg
EUR 2640

Amyloid beta A4 protein

AP80183 1mg
EUR 2640

Amyloid beta A4 protein

AP80191 1mg
EUR 2640

Amyloid beta Protein (20-29)

20-abx266170
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  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (33-42)

20-abx266417
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  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (20-29)

abx266170-200tests 200 tests
EUR 287.5

Amyloid beta Protein (20-29)

abx266170-500tests 500 tests
EUR 400

Amyloid beta Protein (33-42)

abx266417-1ml 1 ml
EUR 500

Amyloid beta Protein (33-42)

abx266417-200l 200 µl
EUR 337.5

Amyloid beta Protein (29-40)

abx266679-1ml 1 ml
EUR 387.5

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