Amyloid

Amyloid Beta Protein

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Major description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current contained in the vascular amyloid deposits. Aβ40 includes of C-terminal membrane insertion area. It shows structural transition from random coil to a α-helical constructing in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen contained in the hippocampus, neocortex, and amygdala of victims with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation based mostly ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • contained in the temperature based mostly conformational evaluation utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) evaluation
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a facet of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

 

amyloid
amyloid

Reconstitution

For maximal pure prepare, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Utterly completely different Notes

Lyophilized from 0.1% TFA in H2O

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology contained in the human ideas and the diploma of scientific dementia. Current advances in our understanding of the event of amyloid pathology have helped remedy this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in fairly a number of swimming swimming swimming pools, can be additional fastidiously associated to illness state.

The composition of those swimming swimming swimming pools of Aβ exhibits totally fully completely different populations of amyloid deposits, and has express correlates with the scientific standing of the affected person. Imaging utilized sciences, together with new amyloid imaging brokers based totally completely on the chemical constructing of histologic dyes, in the mean time are making it doable to trace amyloid pathology together with illness enchancment contained in the residing affected particular person. Curiously, these approaches degree out that the Aβ deposited in AD is completely fully completely different from that present in animal fashions.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

beta Amyloid 40 protein

30R-3013 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

[Lys15]-Amyloid beta Protein (15-21)

20-abx265888
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (25-35) amide

20-abx266281
  • EUR 594.00
  • EUR 978.00
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Amyloid Beta (A4) Precursor Protein

PR27172 10 ug
EUR 381.6

Amyloid Beta A4 Protein (APP) Antibody

20-abx137437
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Amyloid Beta A4 Protein (APP) Antibody

20-abx210155
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Amyloid Beta A4 Protein (APP) Antibody

abx230512-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx230513-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx224105-100ug 100 ug
EUR 493.2

Amyloid Beta A4 Protein (APP) Antibody

abx146535-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx146606-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx412477-01mg 0.1 mg
EUR 644.4

Amyloid Beta A4 Protein (APP) Antibody

abx412509-01ml 0.1 ml
EUR 844.8

Amyloid Beta A4 Protein (APP) Antibody

abx412510-01ml 0.1 ml
EUR 844.8

Amyloid Beta A4 Protein (APP) Antibody

abx027538-400ul 400 ul
EUR 627.6

Amyloid Beta A4 Protein (APP) Antibody

abx027538-80l 80 µl
EUR 343.2

Amyloid Beta A4 Protein (APP) Antibody

abx032791-400ul 400 ul
EUR 627.6

Amyloid Beta A4 Protein (APP) Antibody

abx032791-80l 80 µl
EUR 343.2

Amyloid Beta A4 Protein (APP) Antibody

abx032792-400ul 400 ul
EUR 627.6

Leave a Comment

Your email address will not be published.