HNS Antibody

HNS Antibody

Abstract

Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated to the bacterial nucleoid. We used chromatin immunoprecipitation to search out out the binding web sites of H-NS and RNA polymerase on the Salmonella enterica serovar Typhimurium chromosome. We found that H-NS would not bind to actively transcribed genes and would not co-localize with RNA polymerase. This reveals that H-NS principally silences gene expression by proscribing the entry of RNA polymerase to the DNA. H-NS had beforehand been confirmed to preferentially bind to curved DNA in vitro. In precise reality, on the genomic diploma we discovered that the extent of H-NS binding correlates greater with the AT-content of DNA.

That’s extra more likely to have evolutionary penalties because of we current that H-NS binds to many Salmonella genes acquired by lateral gene swap, and capabilities as a gene silencer. The eradicating of H-NS from the cell causes un-controlled expression of quite a few Salmonella pathogenicity islands, and we reveal that this has deleterious penalties for bacterial well being. Our discovery of this novel place for H-NS might have implications for the acquisition of abroad genes by enteric micro organism.

Synopsis

In newest a very long time, gene silencing has been well-characterised in vegetation and animals, and consists of the prevention of transcription by DNA-methylation and histone-modification, or interference with translation by small RNA molecules. This case of PLoS Pathogens tales the invention that worldwide gene silencing moreover occurs in micro organism. The novel mechanism is mediated by the extraordinarily appreciable histone-like nucleoid structuring protein (H-NS), which blocks the expression of 254 genes in wild-type Salmonella. Lots of these genes had been acquired by means of horizontal gene swap, along with pathogenicity islands, and these are silenced by the binding of H-NS to AT-rich chromosomal areas. The look at reveals that H-NS prevents the uncontrolled transcription of genes inside pathogenicity islands to ensure that bacterial well being is maintained. It is urged that H-NS performs a activity in bacterial evolution by influencing every the acquisition and maintenance of abroad DNA.

hns, Polyclonal Antibody
hns, Polyclonal Antibody
Synonyms Anti-Human IgG Fc Monoclonal Secondary Antibody (Min X Ms, Rt, Rb, Ch, Gt)
Description Often, goat anti-human or donkey anti-human IgG polyclonal antibodies are used as a result of the secondary antibody to detect human main antibodies. Nonetheless, since polyclonal antibodies can acknowledge many epitopes, the background and the cross reactivity throughout the assays is generally extreme, making the outcomes exhausting to interpret.
To attenuate the background and cross reactivity and improve the lot-to-lot consistency, a singular GenScript Mouse Anti-Human IgG Fc Antibody (50B4A9)[HRP], mAb has been developed to be used as a secondary antibody. The prevalence of this antibody is that it might be used as an idiotype antibody to detect drug metabolism in vivo.
Host Species Mouse
Antigen Species Human
Conjugation Peroxidase (Horseradish)
Immunogen Human IgG(H&L)
Purification Protein A affinity column

 

 

Working concentrations for explicit features have to be determined by the investigator. The appropriate concentrations may be affected by main antibody affinity, antigen focus, the sensitivity of the technique of detection, temperature, the scale of the incubations, and completely different elements. The suitability of this antibody for features except for these listed beneath has not been determined. The following focus ranges are actually useful starting elements for this product.

 

Anti-NHS antibodies are supplied by fairly just a few suppliers. This purpose gene encodes the protein ‘NHS actin remodeling regulator’ in individuals and could also be known as CTRCT40, CXN, SCML1, Nance-Horan syndrome protein, and Nance-Horan syndrome (congenital cataracts and dental anomalies). Structurally, the protein is reported to be 179.1 kilodaltons in mass. Based mostly totally on gene title, canine, porcine, monkey, mouse and rat orthologs could also be found. For further full antibody product information (akin to immunogen, specificity, features, and additional), go to the supplier internet web page.

 

SerRatia marcescens DNA-binding protein H-NS (hns)

1-CSB-EP324759SYN
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 19.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant SerRatia marcescens DNA-binding protein H-NS(hns) expressed in E.coli

H2B Antibody Antibody

AF4659 200ul
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Description: H2B Antibody Antibody detects endogenous levels of H2B.

CD11b Antibody Antibody

ABD2911 100 ug
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anti- Antibody^Polyclonal antibody control antibody

LSMab09882 100 ug
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Ly1 Antibody Reactive (LYAR) Antibody

20-abx123734
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx036399-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx008109
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

20-abx004855
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx014333
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx324434
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319900
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319901
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319905
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319913
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx311665
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx234901-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx230204-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Anti-Anti-SEPT2 Antibody antibody

STJ28365 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT6 antibody antibody

STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Anti-Anti-SEPT2 Antibody antibody

STJ25475 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-SEPT8 Antibody antibody

STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT9 Antibody antibody

STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

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