PRODUCT DESCRIPTION

Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker associated to blocking all forms of Fc receptors equal to Fc-gamma receptors of sort I,II and III; Fc -epsilon receptors sort I and II; Fc –alpha receptors, Fcα/ µR and FcRn. Innovex Fc Blocker does NOT comprise antibodies, Immunoglobulins or immunoglobulin fragments. INNOVEX Fc Blocker is probably universally utilized to dam all forms of Fc receptors in all-species together with human, mouse and all-animals This Widespread Fc Block could possibly be utilized in quite a lot of Immunoassays equal to IHC, ICC, Immunofluorescence and Circulation cytometry. INNOVEX UNIVERSAL Fc BLOCK is appropriate for blocking Fc receptors in frozen and paraffin tissuesections and cyto preps of human and all-animal species. INNOVEX Fc Blocker might also be sometimes used for eliminating background staining in ideas cells/tissues.

INTRODUCTION

Fc receptors (FcRs) are glycoproteins of approximate molecular weights of 50-70 kD. They’re extensively expressed
all by the use of the immune cells. Fc receptors are current on leukocytes equal to monocytes, tissue macrophages, B cells, granulocytes (eosinophils, basophils, neutrophils), NK cells and a few T cells. Fc receptors are furthermore current on mast cells, follicular dendritic cells, epithelial cells, endothelial cells, hepatocytes and langerhans cells amongst others. There are a collection of forms of Fc receptors (FcR) which may be categorised based mostly on the antibody that they acknowledge. There are people who’ve good affinity for the Fc area of monomeric IgG antibody and are often called Fc-Gamma receptors, people who bind to IgA antibody are often called Fc-alpha receptors and people who bind IgE antibody are often called Fc-epsilon receptors.

Non express Fc receptors staining in assays equal to IHC, ICC, Immunofluorescence (IF) and movement cytometry would possibly end up from the binding of the Fc area of the first and/or secondary antibody or immunoglobulin isotypes to the Fc receptors of the cells. Eliminating Fc receptor staining is fascinating in IHC, ICC, IF and Circulation cytometry assays for the objective of proper knowledge analysis.
For IHC, ICC, IF testing: The binding of the Fc area of predominant and/or secondary antibody and immunoglobulin
isotypes to the Fc receptors current on cells/tissues give rise to non-specific Fc receptor staining. Specimens wealthy in Fc receptors embrace spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others embrace tissues and cell preps meant for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor cell traces that particular Fc receptors. To avoid Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a brief interval earlier to utility of predominant antibody or immunoglobulin isotypes (See instruction part of this knowledge sheet).

For Circulation cytometry assays: Fc receptors are current on leukocytes (white blood cells), many cell traces together with utterly totally different
cell varieties in each human and animal cells/tissues. Fc receptors affords rise to non-specific Fc receptor-staining in movement
cytometry assays by binding of Fc area of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc receptors staining is probably eradicated by incubating cells with INNOVEX Fc Receptor Blocker for quite a lot of Circulation cytometry assays equal to CD phenotyping, leukemia typing and cell line evaluation. (See instruction part of this knowledge sheet).

 

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