PRODUCT DESCRIPTION

Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker associated to blocking all forms of Fc receptors equal to Fc-gamma receptors of sort I,II and III; Fc -epsilon receptors sort I and II; Fc –alpha receptors, Fcα/ µR and FcRn. Innovex Fc Blocker does NOT comprise antibodies, Immunoglobulins or immunoglobulin fragments. INNOVEX Fc Blocker is probably universally utilized to dam all forms of Fc receptors in all-species together with human, mouse and all-animals This Widespread Fc Block could possibly be utilized in quite a lot of Immunoassays equal to IHC, ICC, Immunofluorescence and Circulation cytometry. INNOVEX UNIVERSAL Fc BLOCK is appropriate for blocking Fc receptors in frozen and paraffin tissuesections and cyto preps of human and all-animal species. INNOVEX Fc Blocker might also be sometimes used for eliminating background staining in ideas cells/tissues.

INTRODUCTION

Fc receptors (FcRs) are glycoproteins of approximate molecular weights of 50-70 kD. They’re extensively expressed
all by the use of the immune cells. Fc receptors are current on leukocytes equal to monocytes, tissue macrophages, B cells, granulocytes (eosinophils, basophils, neutrophils), NK cells and a few T cells. Fc receptors are furthermore current on mast cells, follicular dendritic cells, epithelial cells, endothelial cells, hepatocytes and langerhans cells amongst others. There are a collection of forms of Fc receptors (FcR) which may be categorised based mostly on the antibody that they acknowledge. There are people who’ve good affinity for the Fc area of monomeric IgG antibody and are often called Fc-Gamma receptors, people who bind to IgA antibody are often called Fc-alpha receptors and people who bind IgE antibody are often called Fc-epsilon receptors.

Non express Fc receptors staining in assays equal to IHC, ICC, Immunofluorescence (IF) and movement cytometry would possibly end up from the binding of the Fc area of the first and/or secondary antibody or immunoglobulin isotypes to the Fc receptors of the cells. Eliminating Fc receptor staining is fascinating in IHC, ICC, IF and Circulation cytometry assays for the objective of proper knowledge analysis.
For IHC, ICC, IF testing: The binding of the Fc area of predominant and/or secondary antibody and immunoglobulin
isotypes to the Fc receptors current on cells/tissues give rise to non-specific Fc receptor staining. Specimens wealthy in Fc receptors embrace spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others embrace tissues and cell preps meant for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor cell traces that particular Fc receptors. To avoid Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a brief interval earlier to utility of predominant antibody or immunoglobulin isotypes (See instruction part of this knowledge sheet).

For Circulation cytometry assays: Fc receptors are current on leukocytes (white blood cells), many cell traces together with utterly totally different
cell varieties in each human and animal cells/tissues. Fc receptors affords rise to non-specific Fc receptor-staining in movement
cytometry assays by binding of Fc area of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc receptors staining is probably eradicated by incubating cells with INNOVEX Fc Receptor Blocker for quite a lot of Circulation cytometry assays equal to CD phenotyping, leukemia typing and cell line evaluation. (See instruction part of this knowledge sheet).

 

Enhanced Universal IHC Diluent/Blocker/Stabilizer
85R-1021E	Fitzgerald	100 ml	EUR 224.4
Description: Enhanced Universal Diluent/Blocker/Stabilizer for use in IHC

VAHTS Target Capture Universal Blockers and Post-PCR Primer Mix for MGI-SI
NCM101-01	Vazyme	24 rxns	EUR 528

VAHTS Target Capture Universal Blockers and Post-PCR Primer Mix for MGI-SI
NCM101-02	Vazyme	96 rxns	EUR 1751.2

VAHTS Target Capture Universal Blockers and Post-PCR Primer Mix for Illumina-TS
NC101-01	Vazyme	24 rxns	EUR 528

VAHTS Target Capture Universal Blockers and Post-PCR Primer Mix for Illumina-TS
NC101-02	Vazyme	96 rxns	EUR 1751.2

10 x Universal Blocking Buffer
GR103005	Genorise Scientific	200 mL	EUR 129

Fc Receptor Blocker, 60 ml; Ready-To-Use
NB309	Innovex	60 ml	EUR 745
Description: Fc Receptor Blocker, 60 ml; Ready-To-Use

Fc Receptor Blocker, 15 ml; Ready-To-Use
NB309-15	Innovex	15 ml	EUR 295
Description: Fc Receptor Blocker, 15 ml; Ready-To-Use

Fc Receptor Blocker, 30 ml; Ready-To-Use
NB309-30	Innovex	30 ml	EUR 425
Description: Fc Receptor Blocker, 30 ml; Ready-To-Use

Fc Receptor Blocker; 4X Concentrate, 15 ml Conce
NB309-4X-15	Innovex	15 ml of 4X	EUR 765
Description: Fc Receptor Blocker; 4X Concentrate, 15 ml Concentrate

Fc Receptor Blocker; 4X Concentrate, 40 ml Conce
NB309-4X-40	Innovex	40 ml of 4X concentrate	EUR 1550
Description: Fc Receptor Blocker; 4X Concentrate, 40 ml Concentrate

Azide-Free Fc Receptor Blocker, 60 ml (Large volum
NB335-60	Innovex	60 ml	EUR 755
Description: Azide-Free Fc Receptor Blocker, 60 ml (Large volume) Ready-To-Use

Fc Receptor Blocker, 5 ml (trial size); Ready-To-U
NB309-5S	Innovex	5 ml	EUR 129
Description: Fc Receptor Blocker, 5 ml (trial size); Ready-To-Use

Universal platform
INC1112	Scientific Laboratory Supplies	EACH	EUR 1434

Universal Attachment
MIX1320	Scientific Laboratory Supplies	EACH	EUR 286.8

Universal V1-Puck
M-CP-111-021	MiTeGen	1 PUCK	EUR 350
Description: Universal V1-Puck

Universal Oven UN30
OVE8314	Scientific Laboratory Supplies	EACH	EUR 1672.8

Universal Oven UN55
OVE8316	Scientific Laboratory Supplies	EACH	EUR 1952.4

Universal Oven UN75
OVE8318	Scientific Laboratory Supplies	EACH	EUR 2028

Universal Oven UF30
OVE8332	Scientific Laboratory Supplies	EACH	EUR 1911.6

Universal Oven UF55
OVE8334	Scientific Laboratory Supplies	EACH	EUR 2306.4