Natural products, which can be isolated from living organisms around the world, have played an important role in drug discovery since ancient times. However, it has become more challenging to identify novel molecules structurally with promising biological activities for pharmaceutical development, especially because the methodology is limited to their acquisition. In this review, we summarize our research recently that activates the potential biosynthesis of fungal filaments by genetic engineering to utilize the flow of metabolism for natural product production that has never happened before.
The recent revolution in the genome sequencing technology allows accumulated a large amount of information about biosynthetic genes, molecular construction blueprint. Utilizing the specified heterologist expression system, activation of specific path transcription factors coupled with the knockout system strategy, and manipulating the global regulatory gene, biosintetic genes are exploited to activate the biosynthetic pathways and describe encoded enzyme functions. We show that this methodology is useful for acquiring fungal assets for drug discovery. These studies also allow the investigation of the molecular function of natural products in the development of fungi.
Virtual screening and molecular simulation study database natural products for lead identification novel novel coronavirus protease inhibitors
3CL LIKE PROTEASE (3CLPRO or MPRO) is one of the main proteases of 2019-Ncov. 3CLPRO is a nontructural protein of SARS-COV and has an important role in viral replication and transcription, thus, can be a potential target for the development of anti-SARS drugs. This study employs a ligand and structural-based approach to identify the effective inhibitor of Protease 2019-NCOV. E-pharmacophore developed from a virtual hit produced by 3CLPro-1, which is worn through the possibility of drugs and filter pain to eliminate disturbing compounds.
A further comprehensive docking study, free energy calculations and admation studies produce two lead virtual-molport-000-410-348 and molport-002-530-156. MOLPORT-000-410-348 and MOLPORT-002-530-156 compounds display good docking scores from -12.09 and -13.38 kcal / mol and free binder energy -63.34 ± 2.03 and -61.52 ± 2.24 kcal / mole. Compounds also showcase Predike Profile predictions and subject to Dynamic Molecular Studies (MD). MD simulation produces a stable complex of these ligands with 3CLPRO proteins and RMSD ligands within acceptable limits. Communicated by Ramaswamy H. Sarma.
Relationship between activities, molecular docking, and molecular dynamic studies from expending from marine natural products with anti-HIV activity
HIV-1 infection is a global epidemic whose treatment is limited to the majority by viral resistance and side effects. Natural products from algae have been studied for years, including antivirus, becoming an alternative to the design of anti-HIV drugs. Because natural product insulation can be in the form of obstacles, molecular modeling is an important tool for studying these compounds. Here, relationships of activities, molecular docking, and molecular dynamic studies are carried out to direct the study of ten natural marine products with anti-HIV activity.
In the relationship between activities, the descriptor is identified associating the activity of anti-HIV five by passing with possible actions on the Alostalister transcriptase site back. Diarpene was evaluated by molecular docking, and was identified that only dolabelladirioletririol was interacting on the alosteric site. Molecular dynamics suggest that dolabelladienetririol can disrupt the RNA virus that binds for HIV-1 RT by inducing changes in enzyme conformation. Also, in Silico’s simulation, predict that the dolabelladiriol presents high
Molecular genome features related to in vitro responses from NCI-60 cancer cell line panels to natural products
Natural products remain a significant source of anti-cancer chemotherapy. Searching for drugs targeted for cancer treatment includes consideration of natural products that can provide new opportunities for anti-tumor cytotoxicity as a single agent or in combination therapy. We examine the association of molecular genome features in the NCI-60 cancer cell line panel well with in vitro responses to treatment with 1,302 small molecules that include natural products, semi-synthetic natural products, and synthetic compounds based on natural products Farmacophore from the therapy program Progression of national national cancer institute database. These compounds are obtained from various plant, sea and microbial species.
Molecular information used for analysis including expression size for 23,059 annotation transcripts, LNCRNAS, and MIRNAS, and data on a single nucleotide variant that changes protein in 211 genes related to cancer. We found the associations of various genes including SLFN11, CYP2J2, EFX1, GPC1, ELF3, and MGMT involved in improving DNA damage, family members of notch, ABC and SLC Transporter, and both mutations in Tyrosine and Braf V600e kinases with NCI response with NCI -60 for the specific category of natural products. Hierarchical clustering identifies a group of natural products that correlate with certain action mechanisms.
In particular, some natural product clusters are associated with the expression of the SLFN11 gene, indicating that the potential actions of this compound can involve damage to DNA. The association between gene expression or changes in genome genomes is relevant functionally with cancer cell responses to natural products providing new information about the potential mechanism of action from a group of potential biological compounds. This information will help the discovery of drugs in the future and in the design of new cancer chemotherapy agents targeted.
A new approach based on the polyethylene form of multi-ultra high molecular weight glued to make bone replacement products
Three types of glue based on Tiol-ENE reactions, polyvinyl alcohol (PVA) / cellulose, and phenol formaldehyde is prepared and applied to the weight of the modified molecular weight polyethylene weight (UHMWPE) grafted by cellulose. Compared to unmodified UHMWPE samples, the T-Peel test in the modified UHMWPE film and grafted shows an increase in the value of skin strength for glue based on the reaction of Tiol-ENE, PVA / cellulose, and formaldehyde phenol by 40, 29, and 41 times, each each. The maximum peeled strength value of 0.62 kg / cm is obtained so that glue based on formaldehyde phenol.
 Silica gel 230 - 400 mesh |
|||
| GRM7484-500G | EWC Diagnostics | 1 unit | EUR 13.6 |
|
Description: Silica gel 230 - 400 mesh |
|||
 Silica Gel 60-200 mesh |
|||
| 40449 | Sisco Laboratories | 500 Gms | EUR 3.83 |
|
Description: Part A |
|||
 Silica Gel 60-120 mesh |
|||
| 65856 | Sisco Laboratories | 500 Gms | EUR 3.22 |
|
Description: Part A |
|||
 Silica Gel 100-200 mesh |
|||
| 95178 | Sisco Laboratories | 500 Gms | EUR 3.22 |
|
Description: Part A |
|||
 Silica gel 100 - 200 mesh |
|||
| GRM7479-25KG | EWC Diagnostics | 1 unit | EUR 515.93 |
|
Description: Silica gel 100 - 200 mesh |
|||
Silica gel 100 - 200 mesh |
|||
| GRM7479-500G | EWC Diagnostics | 1 unit | EUR 11.47 |
|
Description: Silica gel 100 - 200 mesh |
|||
 Silica gel 60 - 120 mesh |
|||
| GRM7477-25KG | EWC Diagnostics | 1 unit | EUR 420.18 |
|
Description: Silica gel 60 - 120 mesh |
|||
Silica gel 60 - 120 mesh |
|||
| GRM7477-500G | EWC Diagnostics | 1 unit | EUR 9.34 |
|
Description: Silica gel 60 - 120 mesh |
|||
 Silica gel 60 - 200 mesh |
|||
| GRM7478-500G | EWC Diagnostics | 1 unit | EUR 9.45 |
|
Description: Silica gel 60 - 200 mesh |
|||
 Silica Gel Grade 03 8 Mesh |
|||
| S02570 | Pfaltz & Bauer | 1KG | EUR 85.3 |
|
Description: CAS N° 7631-86-9 |
|||
 Silica Gel Grade 408 12-24 Mesh |
|||
| S02577 | Pfaltz & Bauer | 500G | EUR 219.6 |
|
Description: CAS N° 7631-86-9 |
|||
) Silica Gel Grade 40 -6+12 Mesh (1680-3350 microns) |
|||
| S02572 | Pfaltz & Bauer | 250G | EUR 119.2 |
|
Description: CAS N° 7631-86-9 |
|||
 (Coarse), 5-8 mesh) Silica Gel Blue (Self Indicating) (Coarse), 5-8 mesh |
|||
| 85148 | Sisco Laboratories | 500 Gms | EUR 3.63 |
|
Description: Part A |
|||
 Silica Gel |
|||
| 30615-85 | NACALAI TESQUE | 500G | EUR 19.6 |
Silica Gel |
|||
| 30619-45 | NACALAI TESQUE | 500G | EUR 19.6 |
Silica Gel |
|||
| 17091-55 | NACALAI TESQUE | 500G | EUR 12.25 |
Silica Gel |
|||
| 17092-45 | NACALAI TESQUE | 500G | EUR 19.6 |
 Silica gel |
|||
| GRM151-1KG | EWC Diagnostics | 1 unit | EUR 11.28 |
|
Description: Silica gel |
|||
Silica gel |
|||
| GRM151-500G | EWC Diagnostics | 1 unit | EUR 6.93 |
|
Description: Silica gel |
|||
Silica gel |
|||
| GRM151-5KG | EWC Diagnostics | 1 unit | EUR 50.46 |
|
Description: Silica gel |
|||
 Silica Gel G for TLC, 325mesh, w/ CaSO4 |
|||
| 51849 | Sisco Laboratories | 500 Gms | EUR 3.69 |
|
Description: Part A |
|||
 Silica Gel H for TLC, 325mesh, w/o CaSO4 |
|||
| 52797 | Sisco Laboratories | 500 Gms | EUR 3.69 |
|
Description: Part A |
|||
 Silica Gel 60 |
|||
| 30721-01 | NACALAI TESQUE | 1KG | EUR 81.9 |
Silica Gel 60 |
|||
| 30721-14 | NACALAI TESQUE | 5KG | EUR 298.9 |
Silica Gel 60 |
|||
| 30721-85 | NACALAI TESQUE | 500G | EUR 49 |
Silica Gel 60 |
|||
| 30724-55 | NACALAI TESQUE | 500G | EUR 27.3 |
Silica Gel 60 |
|||
| 30724-71 | NACALAI TESQUE | 1KG | EUR 49.7 |
Silica Gel 60 |
|||
| 30724-84 | NACALAI TESQUE | 5KG | EUR 205.1 |
 Silica gel H |
|||
| GRM602-500G | EWC Diagnostics | 1 unit | EUR 10.29 |
|
Description: Silica gel H |
|||
 Silicon carbide 400 mesh |
|||
| GRM7488-1KG | EWC Diagnostics | 1 unit | EUR 70.04 |
|
Description: Silicon carbide 400 mesh |
|||
Silicon carbide 400 mesh |
|||
| GRM7488-250G | EWC Diagnostics | 1 unit | EUR 18.94 |
|
Description: Silicon carbide 400 mesh |
|||
 Silica gel GF 254 |
|||
| GRM367-500G | EWC Diagnostics | 1 unit | EUR 64.32 |
|
Description: Silica gel GF 254 |
|||
 Silica Gel 120, spherical |
|||
| 30734-41 | NACALAI TESQUE | 1KG | EUR 56.7 |
 Silica Gel 60, spherical |
|||
| 30731-42 | NACALAI TESQUE | 25KG | EUR 957.6 |
Silica Gel 60, spherical |
|||
| 30731-71 | NACALAI TESQUE | 1KG | EUR 51.8 |
 Drying Reagent, Silica Gel |
|||
| DSG110 | Bio Basic | 1Kg | EUR 91.32 |
 Silica Gel GF254 for TLC, 325mesh, w/ Fluorescent Indicator w/ CaSO4 |
|||
| 38062 | Sisco Laboratories | 500 Gms | EUR 26.68 |
|
Description: Part A |
|||
 Silica gel G For TLC |
|||
| GRM7480-500G | EWC Diagnostics | 1 unit | EUR 10.87 |
|
Description: Silica gel G For TLC |
|||
 Silica Gel with 3% AgNO3 |
|||
| S450270 | Toronto Research Chemicals | 10g | EUR 800 |
 Silica Gel HF254 for TLC, 325mesh, w/ Fluorescent Indicator w/o CaSO4 |
|||
| 29774 | Sisco Laboratories | 500 Gms | EUR 26.68 |
|
Description: Part A |
|||
 Silica gel HF 254 For TLC |
|||
| GRM7482-500G | EWC Diagnostics | 1 unit | EUR 70.56 |
|
Description: Silica gel HF 254 For TLC |
|||
) Silica Gel Fumed 200 (Hydrophilic) |
|||
| 84210 | Sisco Laboratories | 100 Gms | EUR 3.22 |
|
Description: Part A |
|||
 Silica Gel 60, spherical, neutral |
|||
| 30511-06 | NACALAI TESQUE | 5KG | EUR 343 |
Silica Gel 60, spherical, neutral |
|||
| 30511-22 | NACALAI TESQUE | 25KG | EUR 1540 |
Silica Gel 60, spherical, neutral |
|||
| 30511-35 | NACALAI TESQUE | 500G | EUR 57.4 |
Silica Gel 60, spherical, neutral |
|||
| 30511-51 | NACALAI TESQUE | 1KG | EUR 98 |
Silica Gel 60, spherical, neutral |
|||
| 30511-64 | NACALAI TESQUE | 100G | EUR 21 |
Silica Gel 60, spherical, neutral |
|||
| 30518-65 | NACALAI TESQUE | 500G | EUR 42 |
Silica Gel 60, spherical, neutral |
|||
| 30518-81 | NACALAI TESQUE | 1KG | EUR 66.5 |
Silica Gel 60, spherical, neutral |
|||
| 30518-94 | NACALAI TESQUE | 100G | EUR 17.5 |
 Silica Gel, 40-63 Micron Particles |
|||
| S450200 | Toronto Research Chemicals | 1kg | EUR 787 |
|
Description: 112926-00-8 |
|||
 Silica Gel, 35-70 Micron Particles |
|||
| S450400 | Toronto Research Chemicals | 2.5kg | EUR 667 |
|
Description: 112926-00-6 |
|||
 Silica gel orange 360 g - EACH |
|||
| DD490938 | Scientific Laboratory Supplies | EACH | EUR 87.75 |
 Silica Gel Large Pore 70 microns |
|||
| S02580 | Pfaltz & Bauer | 100G | EUR 102.24 |
|
Description: CAS N° 1343-98-2 |
|||
 Silica Gel In Bag, 5G, 100/Pk |
|||
| DSG111 | Bio Basic | 1PK, 100UNIT | EUR 73.57 |
 Silica Gel Grade 12 High Purity Chromatographic Gel 28-20 |
|||
| S02571 | Pfaltz & Bauer | 1KG | EUR 140.95 |
|
Description: CAS N° 112945-52-5 |
|||
 5g Silica Gel Sachets In Tyvek - PK1000 |
|||
| X17976 | Scientific Laboratory Supplies | PK1000 | EUR 130.72 |
, 2-5mm) Silica Gel Orange (Self Indicating), 2-5mm |
|||
| 71548 | Sisco Laboratories | 500 Gms | EUR 4.11 |
|
Description: Part A |
|||
) 3-Aminopropyl-funtionalized Silica Gel (40-63 μm) |
|||
| A450215 | Toronto Research Chemicals | 1g | EUR 132 |
 Silica Gel Grade 923 High Purity Chromatographic_x000D_ |
|||
| S02578 | Pfaltz & Bauer | 100G | EUR 239.23 |
|
Description: CAS N° 7631-86-9 |
|||
 Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254 | Glentham Life Sciences | 500g | EUR 159.23 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-1 | Glentham Life Sciences | 1 | EUR 47.4 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-1KG | Glentham Life Sciences | 1 kg | EUR 93.6 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-5 | Glentham Life Sciences | 5 | EUR 174 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-500 | Glentham Life Sciences | 500 | EUR 27.8 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-500G | Glentham Life Sciences | 500 g | EUR 69.6 |
Silica Gel, pore size ~25A, 2 - 5 mm beads |
|||
| GX6254-5KG | Glentham Life Sciences | 5 kg | EUR 246 |
 Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287 | Glentham Life Sciences | 500g | EUR 159.23 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-1 | Glentham Life Sciences | 1 | EUR 47.4 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-1KG | Glentham Life Sciences | 1 kg | EUR 93.6 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-5 | Glentham Life Sciences | 5 | EUR 174 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-500 | Glentham Life Sciences | 500 | EUR 27.8 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-500G | Glentham Life Sciences | 500 g | EUR 69.6 |
Silica Gel, pore size ~25A, 1 - 3 mm beads |
|||
| GX9287-5KG | Glentham Life Sciences | 5 kg | EUR 246 |
) C18 Silica Gel (>10% C-18; Capped With TMS) |
|||
| S452500 | Toronto Research Chemicals | 50g | EUR 265 |
 Silica gel, pore size 60A, particle size 40-63 micron |
|||
| GX9977 | Glentham Life Sciences | 1kg | EUR 49.79 |
Silica gel, pore size 60A, particle size 40-63 micron |
|||
| GX9977-1 | Glentham Life Sciences | 1 | EUR 54.4 |
Silica gel, pore size 60A, particle size 40-63 micron |
|||
| GX9977-1KG | Glentham Life Sciences | 1 kg | EUR 102 |
 Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162 | Glentham Life Sciences | 500g | EUR 195.68 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-1 | Glentham Life Sciences | 1 | EUR 58.4 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-1KG | Glentham Life Sciences | 1 kg | EUR 106.8 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-5 | Glentham Life Sciences | 5 | EUR 213.7 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-500 | Glentham Life Sciences | 500 | EUR 33.1 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-500G | Glentham Life Sciences | 500 g | EUR 76.8 |
Silica Gel, self-indicating, blue to pink, 2 - 5 mm beads |
|||
| GE5162-5KG | Glentham Life Sciences | 5 kg | EUR 294 |
 Silica Gel, self-indicating, orange to green, 2 - 5 mm beads |
|||
| GE5612 | Glentham Life Sciences | 500g | EUR 208.67 |
 DiagNano™ Silica Particles, 400 nm |
|||
| DNG-B008 | Creative Diagnostics | 10 mL | EUR 560 |
 Silicon carbide 220 mesh |
|||
| GRM7487-1KG | EWC Diagnostics | 1 unit | EUR 84.04 |
|
Description: Silicon carbide 220 mesh |
|||
Silicon carbide 220 mesh |
|||
| GRM7487-250G | EWC Diagnostics | 1 unit | EUR 24.12 |
|
Description: Silicon carbide 220 mesh |
|||
 Silicon powder 99.999% -325 Mesh |
|||
| S02610 | Pfaltz & Bauer | 25G | EUR 352.06 |
|
Description: CAS N° 7440-21-3 |
|||
 Silicon carbide 99% -100 Mesh |
|||
| S02620 | Pfaltz & Bauer | 500G | EUR 180 |
|
Description: CAS N° 409-21-2 |
|||
 Silicon dioxide 99.5% -325 MESH |
|||
| S02645 | Pfaltz & Bauer | 250G | EUR 137.4 |
|
Description: CAS N° 7631-86-9 |
|||
 DiagNano™ Silica Particles, 700 nm |
|||
| DNG-B011 | Creative Diagnostics | 10 mL | EUR 564 |
 Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|||
| GE9411 | Glentham Life Sciences | 500g | EUR 55.02 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|||
| GE9411-1 | Glentham Life Sciences | 1 | EUR 60.1 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|||
| GE9411-1KG | Glentham Life Sciences | 1 kg | EUR 109.2 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|||
| GE9411-500 | Glentham Life Sciences | 500 | EUR 35.5 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|||
| GE9411-500G | Glentham Life Sciences | 500 g | EUR 79.2 |
 oxide, 99.99%, -100 mesh) Silicon(IV) oxide, 99.99%, -100 mesh |
|||
| GX8518 | Glentham Life Sciences | 50g | EUR 406.18 |
Silicon(IV) oxide, 99.99%, -100 mesh |
|||
| GX8518-250 | Glentham Life Sciences | 250 | EUR 356.8 |
Silicon(IV) oxide, 99.99%, -100 mesh |
|||
| GX8518-50 | Glentham Life Sciences | 50 | EUR 140.2 |
 plates (10 pcs)) Foil pouch and silica gel pack for storage of microtitre (ELISA) plates (10 pcs) |
|||
| 100191 | BioServUK | 10 pcs | EUR 22 |
|
Description: Foil pouch and silica gel pack for storage of microtitre (ELISA) plates (10 pcs) |
|||
 Silicon Metal powder, 98.5%, -200 mesh |
|||
| 73081 | Sisco Laboratories | 100 Gms | EUR 2.4 |
|
Description: Part B |
|||
 Silver Metal powder, 99.9%, -400 mesh |
|||
| 32422 | Sisco Laboratories | 10 Gms | EUR 24.75 |
|
Description: Part B |
|||
 Silicon nitride -325 or -2500 mesh sizes |
|||
| S02660 | Pfaltz & Bauer | 10G | EUR 139.5 |
|
Description: CAS N° 12033-89-5 |
|||
 MagIso™ cfDNA Silica Magnetic Particles, 400 nm |
|||
| WHK-C031 | Creative Diagnostics | 10 ml | EUR 500 |
 Silicon Metal powder, 98.5%, -4 mesh |
|||
| 79427 | Sisco Laboratories | 500 Gms | EUR 9.75 |
|
Description: Part B |
|||
 Silicon Powder -100, +325 mesh, amorphous, 99.999% |
|||
| GX3061 | Glentham Life Sciences | 50g | EUR 973.41 |
Silicon Powder -100, +325 mesh, amorphous, 99.999% |
|||
| GX3061-250 | Glentham Life Sciences | 250 | EUR 840.8 |
Silicon Powder -100, +325 mesh, amorphous, 99.999% |
|||
| GX3061-50 | Glentham Life Sciences | 50 | EUR 236.2 |
 DiagNano™ Plain Silica Particles, Nonporous, 400 nm, Powder |
|||
| DNG-GS355 | Creative Diagnostics | 5 g | EUR 928 |
 Silica |
|||
| si300 | Clemente Associates LLC | 2 ML | EUR 367.5 |
 Zeolite - Mesoporous Silica Molecular Sieve Kit-6 |
|||
| 65276 | Sisco Laboratories | 1 Gms | EUR 124.34 |
|
Description: Part C |
|||
) Zeolite - Mesoporous Silica Nanopowder (SBA-15 Type) |
|||
| 83881 | Sisco Laboratories | 250 Mg | EUR 31.09 |
|
Description: Part C |
|||
Zeolite - Mesoporous Silica Nanopowder (SBA-15 Type) |
|||
| 83881-1 | Sisco Laboratories | 1 Gms | EUR 93.55 |
|
Description: Part C |
|||
) Bromoacetyl resin (200-400 mesh) |
|||
| 4029092.0005 | Bachem | 5 g | EUR 317.94 |
Bromoacetyl resin (200-400 mesh) |
|||
| D-2555.0001 | Bachem | 1.0g | EUR 166.8 |
Bromoacetyl resin (200-400 mesh) |
|||
| D-2555.0005 | Bachem | 5.0g | EUR 529.2 |
 DiagNano™ Li Ion Silica Particles, Nonporous, 400 nm, Powder |
|||
| DNG-GS356 | Creative Diagnostics | 5 g | EUR 928 |
 DiagNano™ PEI Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN27 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ PEI Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN45 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ Carboxyl Mesoporous Silica Particles, 3 μm |
|||
| DNG-C046 | Creative Diagnostics | 10 mL | EUR 1020 |
 DiagNano™ Plain Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN23 | Creative Diagnostics | 5 mL | EUR 928 |
 DiagNano™ Amine Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN25 | Creative Diagnostics | 5 mL | EUR 976 |
 DiagNano™ Thiol Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN29 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ Plain Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN41 | Creative Diagnostics | 5 mL | EUR 928 |
 DiagNano™ Amine Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN43 | Creative Diagnostics | 5 mL | EUR 976 |
 DiagNano™ Thiol Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN47 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ S-S Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN28 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ S-S Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN46 | Creative Diagnostics | 5 mL | EUR 1280 |
 DiagNano™ Carboxyl Mesoporous Silica Nanoparticles, 50 nm |
|||
| WHM-23DN24 | Creative Diagnostics | 5 mL | EUR 976 |
 DiagNano™ Carboxyl Mesoporous Silica Nanoparticles, 100 nm |
|||
| WHM-23DN42 | Creative Diagnostics | 5 mL | EUR 976 |
 Dowex® 50WX2, 200-400 mesh |
|||
| RM2810-250G | EWC Diagnostics | 1 unit | EUR 273.58 |
|
Description: Dowex® 50WX2, 200-400 mesh |
|||
 Dowex® 50WX8, 200-400 mesh |
|||
| RM2815-250G | EWC Diagnostics | 1 unit | EUR 424.54 |
|
Description: Dowex® 50WX8, 200-400 mesh |
|||
) Zeolite - Mesoporous Silica Nanopowder (3D-Cubic MCM-48 Type) |
|||
| 63876 | Sisco Laboratories | 250 Mg | EUR 143.88 |
|
Description: Part C |
|||
Zeolite - Mesoporous Silica Nanopowder (3D-Cubic MCM-48 Type) |
|||
| 63876-1 | Sisco Laboratories | 500 Mg | EUR 210.99 |
|
Description: Part C |
|||
 Amorphous silica |
|||
| HY-154739A | MedChemExpress | Get quote | Ask for price |
|
Description: Amorphous silica can be used as an excipient, such as viscosifier, suspending agent, tablet disintegrating agent, adsorbent dispersing agent as liquid in powders. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. |
|||
Mechanical tests for samples of multi-uhmwpe cylinder shapes, made of porous uhmwpe as a trabecular layer and armored layer (cortical layer) consisting of bulk films and UHMWPE, shows an increase in the mechanical properties of all types of glue, as a result of the existence of the UHMWPE film and Increased number of layers. The strength of the maximum press yield and modulus value of the press for the armored layer (bulk and six layers of UHMWPE film using glue based on the Tiol-ENE reaction) is 44.1 MPa (a 1730 mpa increase (increasing 36%), compared to one layer uhmwpe steel Joint reconstruction.