Natural products, which can be isolated from living organisms around the world, have played an important role in drug discovery since ancient times. However, it has become more challenging to identify novel molecules structurally with promising biological activities for pharmaceutical development, especially because the methodology is limited to their acquisition. In this review, we summarize our research recently that activates the potential biosynthesis of fungal filaments by genetic engineering to utilize the flow of metabolism for natural product production that has never happened before.
The recent revolution in the genome sequencing technology allows accumulated a large amount of information about biosynthetic genes, molecular construction blueprint. Utilizing the specified heterologist expression system, activation of specific path transcription factors coupled with the knockout system strategy, and manipulating the global regulatory gene, biosintetic genes are exploited to activate the biosynthetic pathways and describe encoded enzyme functions. We show that this methodology is useful for acquiring fungal assets for drug discovery. These studies also allow the investigation of the molecular function of natural products in the development of fungi.
Virtual screening and molecular simulation study database natural products for lead identification novel novel coronavirus protease inhibitors
3CL LIKE PROTEASE (3CLPRO or MPRO) is one of the main proteases of 2019-Ncov. 3CLPRO is a nontructural protein of SARS-COV and has an important role in viral replication and transcription, thus, can be a potential target for the development of anti-SARS drugs. This study employs a ligand and structural-based approach to identify the effective inhibitor of Protease 2019-NCOV. E-pharmacophore developed from a virtual hit produced by 3CLPro-1, which is worn through the possibility of drugs and filter pain to eliminate disturbing compounds.
A further comprehensive docking study, free energy calculations and admation studies produce two lead virtual-molport-000-410-348 and molport-002-530-156. MOLPORT-000-410-348 and MOLPORT-002-530-156 compounds display good docking scores from -12.09 and -13.38 kcal / mol and free binder energy -63.34 ± 2.03 and -61.52 ± 2.24 kcal / mole. Compounds also showcase Predike Profile predictions and subject to Dynamic Molecular Studies (MD). MD simulation produces a stable complex of these ligands with 3CLPRO proteins and RMSD ligands within acceptable limits. Communicated by Ramaswamy H. Sarma.
Relationship between activities, molecular docking, and molecular dynamic studies from expending from marine natural products with anti-HIV activity
HIV-1 infection is a global epidemic whose treatment is limited to the majority by viral resistance and side effects. Natural products from algae have been studied for years, including antivirus, becoming an alternative to the design of anti-HIV drugs. Because natural product insulation can be in the form of obstacles, molecular modeling is an important tool for studying these compounds. Here, relationships of activities, molecular docking, and molecular dynamic studies are carried out to direct the study of ten natural marine products with anti-HIV activity.
In the relationship between activities, the descriptor is identified associating the activity of anti-HIV five by passing with possible actions on the Alostalister transcriptase site back. Diarpene was evaluated by molecular docking, and was identified that only dolabelladirioletririol was interacting on the alosteric site. Molecular dynamics suggest that dolabelladienetririol can disrupt the RNA virus that binds for HIV-1 RT by inducing changes in enzyme conformation. Also, in Silico’s simulation, predict that the dolabelladiriol presents high
Molecular genome features related to in vitro responses from NCI-60 cancer cell line panels to natural products
Natural products remain a significant source of anti-cancer chemotherapy. Searching for drugs targeted for cancer treatment includes consideration of natural products that can provide new opportunities for anti-tumor cytotoxicity as a single agent or in combination therapy. We examine the association of molecular genome features in the NCI-60 cancer cell line panel well with in vitro responses to treatment with 1,302 small molecules that include natural products, semi-synthetic natural products, and synthetic compounds based on natural products Farmacophore from the therapy program Progression of national national cancer institute database. These compounds are obtained from various plant, sea and microbial species.
Molecular information used for analysis including expression size for 23,059 annotation transcripts, LNCRNAS, and MIRNAS, and data on a single nucleotide variant that changes protein in 211 genes related to cancer. We found the associations of various genes including SLFN11, CYP2J2, EFX1, GPC1, ELF3, and MGMT involved in improving DNA damage, family members of notch, ABC and SLC Transporter, and both mutations in Tyrosine and Braf V600e kinases with NCI response with NCI -60 for the specific category of natural products. Hierarchical clustering identifies a group of natural products that correlate with certain action mechanisms.
In particular, some natural product clusters are associated with the expression of the SLFN11 gene, indicating that the potential actions of this compound can involve damage to DNA. The association between gene expression or changes in genome genomes is relevant functionally with cancer cell responses to natural products providing new information about the potential mechanism of action from a group of potential biological compounds. This information will help the discovery of drugs in the future and in the design of new cancer chemotherapy agents targeted.
A new approach based on the polyethylene form of multi-ultra high molecular weight glued to make bone replacement products
Three types of glue based on Tiol-ENE reactions, polyvinyl alcohol (PVA) / cellulose, and phenol formaldehyde is prepared and applied to the weight of the modified molecular weight polyethylene weight (UHMWPE) grafted by cellulose. Compared to unmodified UHMWPE samples, the T-Peel test in the modified UHMWPE film and grafted shows an increase in the value of skin strength for glue based on the reaction of Tiol-ENE, PVA / cellulose, and formaldehyde phenol by 40, 29, and 41 times, each each. The maximum peeled strength value of 0.62 kg / cm is obtained so that glue based on formaldehyde phenol.
 Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|
GE9411-1KG |
Glentham Life Sciences |
1 kg |
EUR 109.2 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|
GE9411-500G |
Glentham Life Sciences |
500 g |
EUR 79.2 |
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|
GE9411-1 |
Glentham Life Sciences |
1 |
EUR 60.1 |
|
|
Silica Gel, self-indicating, orange to colourless, 4 - 8 mm beads, cobalt free |
|
GE9411-500 |
Glentham Life Sciences |
500 |
EUR 35.5 |
|
|
) Bromoacetyl resin (200-400 mesh) |
|
D-2555.0001 |
Bachem |
1.0g |
EUR 166.8 |
Bromoacetyl resin (200-400 mesh) |
|
D-2555.0005 |
Bachem |
5.0g |
EUR 529.2 |
 Silica Particles |
|
SIP-05-10 |
Spherotech |
10 mL |
EUR 218.4 |
|
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
Silica Particles |
|
SIP-10-10 |
Spherotech |
10 mL |
EUR 225.6 |
|
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
Silica Particles |
|
SIP-15-10 |
Spherotech |
10 mL |
EUR 237.6 |
|
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
Silica Particles |
|
SIP-30-10 |
Spherotech |
10 mL |
EUR 237.6 |
|
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
Silica Particles |
|
SIP-60-10 |
Spherotech |
10 mL |
EUR 249.6 |
|
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
 Amino Silica Particles |
|
ASIP-30-10 |
Spherotech |
10 mL |
EUR 372 |
|
Description: Amino Silica Particles are non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates. |
 Prefilled 2.0ml tubes, 0.1mm Silica, 1.4 mm Zirconium & 4mm Silica Beads, 50pk |
|
D1034-MX |
Benchmark Scientific |
1 PC |
EUR 178.4 |
 Streptavidin Silica Particles |
|
SVSIP-05-5 |
Spherotech |
5 mL |
EUR 554.4 |
|
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
Streptavidin Silica Particles |
|
SVSIP-10-5 |
Spherotech |
5 mL |
EUR 554.4 |
|
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
Streptavidin Silica Particles |
|
SVSIP-15-5 |
Spherotech |
5 mL |
EUR 554.4 |
|
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
Streptavidin Silica Particles |
|
SVSIP-30-5 |
Spherotech |
5 mL |
EUR 583.2 |
|
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
Streptavidin Silica Particles |
|
SVSIP-60-5 |
Spherotech |
5 mL |
EUR 615.6 |
|
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
) Wang resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1250.0005 |
Bachem |
5.0g |
EUR 138 |
Wang resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1250.0025 |
Bachem |
25.0g |
EUR 385.2 |
Wang resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1250.0100 |
Bachem |
100.0g |
EUR 1096.8 |
 Silica Microspheres - Dry, 0.3um |
|
SS02N-1.5 |
Bangs Laboratories |
1,5 g |
EUR 552.78 |
|
Description: Silica Microspheres - Dry, 0.3um with natural hydroxyl or silanol surface groups. Suitable for use for proteins with low binding capacity. |
 Silica Microspheres - Dry, 0.5um |
|
SS03N-1.5 |
Bangs Laboratories |
1,5 g |
EUR 552.78 |
|
Description: Silica Microspheres - Dry, 0.5um with natural hydroxyl or silanol surface groups. Suitable for use for proteins with low binding capacity. |
 Silica Microspheres - Dry, 1.5um |
|
SS04N-1.5 |
Bangs Laboratories |
1,5 g |
EUR 774.64 |
|
Description: Silica Microspheres - Dry, 1.5um with natural hydroxyl or silanol surface groups. Suitable for use for proteins with low binding capacity. |
 Silica Microspheres - Dry, 4.0um |
|
SS05N-1.5 |
Bangs Laboratories |
1,5 g |
EUR 906.43 |
|
Description: Silica Microspheres - Dry, 4.0um with natural hydroxyl or silanol surface groups. Suitable for use for proteins with low binding capacity. |
 Silica Microspheres - Dry, 5.0um |
|
SS06N-1.5 |
Bangs Laboratories |
1,5 g |
EUR 906.43 |
|
Description: Silica Microspheres - Dry, 5.0um with natural hydroxyl or silanol surface groups. Suitable for use for proteins with low binding capacity. |
) SASRIN resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1295.0001 |
Bachem |
1.0g |
EUR 194.4 |
|
Description: CAS# [124760-64-1] |
SASRIN resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1295.0005 |
Bachem |
5.0g |
EUR 646.8 |
|
Description: CAS# [124760-64-1] |
SASRIN resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1295.0025 |
Bachem |
25.0g |
EUR 2473.2 |
|
Description: CAS# [124760-64-1] |
 Silica Superparamagnetic Particles |
|
SIM-025-10H |
Spherotech |
10mL |
EUR 249.6 |
|
Description: Silica Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules. |
Silica Superparamagnetic Particles |
|
SIM-05-10H |
Spherotech |
10mL |
EUR 279.6 |
|
Description: Silica Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules. |
 Fused Silica Capillary Tubing |
|
CAP-75 |
Next Advance |
1roll |
EUR 267.6 |
|
Description: Capillary for LC/MS columns, 75 um ID, 363um OD, 10 meter length. Includes a cleaving tool. |
 Silica Microspheres, Amine, 0.5um |
|
SA03N-1 |
Bangs Laboratories |
1 g |
EUR 621.95 |
|
Description: Silica Microspheres, Amine, 0.5um are bead platform with improved binding kinetics over planar ssurfaces, robust statistics, flexible silanization chemistries, unique refractive index and density, low autofluorescence, low nonspecific binding of many biomolecules |
 Silica Microspheres, Amine, 1.0um |
|
SA04N-1 |
Bangs Laboratories |
1 g |
EUR 621.95 |
|
Description: Silica Microspheres, Amine, 1.0um are bead platform with improved binding kinetics over planar ssurfaces, robust statistics, flexible silanization chemistries, unique refractive index and density, low autofluorescence, low nonspecific binding of many biomolecules |
 Silica Microspheres, Amine, 5.0um |
|
SA05N-1 |
Bangs Laboratories |
1 g |
EUR 1009.54 |
|
Description: Silica Microspheres, Amine, 5.0um are bead platform with improved binding kinetics over planar ssurfaces, robust statistics, flexible silanization chemistries, unique refractive index and density, low autofluorescence, low nonspecific binding of many biomolecules |
) Merrifield resin (200-400 mesh, 0.80-1.40 mmol/g) |
|
D-1245.0025 |
Bachem |
25.0g |
EUR 181.2 |
|
Description: CAS# [55844-94-5] |
Merrifield resin (200-400 mesh, 0.80-1.40 mmol/g) |
|
D-1245.0100 |
Bachem |
100.0g |
EUR 471.6 |
|
Description: CAS# [55844-94-5] |
 Quantifoil R 1/2 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR-12 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 1/2 ; Gold 400 Mesh 100/pk |
 Quantifoil R 2/4 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR-4 |
MiTeGen |
- |
EUR 925 |
|
Description: Quantifoil R 2/4 ; Gold 400 Mesh 100/pk |
 Quantifoil R 2/1 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR1 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 2/1 ; Gold 400 Mesh 100/pk |
 Quantifoil R 1.2/1.3, Gold 400 mesh 100/pk |
|
M-CEM-Q4100AR1.3 |
MiTeGen |
100 GRIDS |
EUR 820 |
|
Description: Quantifoil R 1.2/1.3, Gold 400 mesh 100/pk |
 Quantifoil R 10/10 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR1010 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 10/10 ; Gold 400 Mesh 100/pk |
 Quantifoil R 10/20; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR1020 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 10/20; Gold 400 Mesh 100/pk |
 Quantifoil R 10/5; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR105 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 10/5; Gold 400 Mesh 100/pk |
 Quantifoil R 17/5; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR175 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 17/5; Gold 400 Mesh 100/pk |
 Quantifoil R 2/2 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR2 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 2/2 ; Gold 400 Mesh 100/pk |
 Quantifoil R 1.2/2.5 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR2.5 |
MiTeGen |
100 GRIDS |
EUR 825 |
|
Description: Quantifoil R 1.2/2.5 ; Gold 400 Mesh 100/pk |
 Quantifoil R 1.2/20; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR21.2 |
MiTeGen |
100 GRIDS |
EUR 825 |
|
Description: Quantifoil R 1.2/20; Gold 400 Mesh 100/pk |
 Quantifoil R 3/3; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR3 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 3/3; Gold 400 Mesh 100/pk |
Quantifoil R 2/4 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR4 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 2/4 ; Gold 400 Mesh 100/pk |
 Quantifoil R 3/5; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR5 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 3/5; Gold 400 Mesh 100/pk |
 Quantifoil R 5/10; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR510 |
MiTeGen |
100 GRIDS |
EUR 895 |
|
Description: Quantifoil R 5/10; Gold 400 Mesh 100/pk |
 Quantifoil R 6/100; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR6100 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 6/100; Gold 400 Mesh 100/pk |
 Quantifoil R 6/6.5; Gold 400 Mesh 100/pk |
|
M-CEM-Q4100AR665 |
MiTeGen |
100 GRIDS |
EUR 1000 |
|
Description: Quantifoil R 6/6.5; Gold 400 Mesh 100/pk |
 Quantifoil R 0.6/1 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q450AR-06 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 0.6/1 ; Gold 400 Mesh 100/pk |
 Quantifoil R 1/4 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q450AR-14 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 1/4 ; Gold 400 Mesh 100/pk |
 Quantifoil R 3.5/1 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q450AR-35 |
MiTeGen |
100 GRIDS |
EUR 925 |
|
Description: Quantifoil R 3.5/1 ; Gold 400 Mesh 100/pk |
 Quantifoil R 5/20 ; Gold 400 Mesh 100/pk |
|
M-CEM-Q450AR-520 |
MiTeGen |
100 GRIDS |
EUR 1010 |
|
Description: Quantifoil R 5/20 ; Gold 400 Mesh 100/pk |
) Aminomethyl resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1005.0005 |
Bachem |
5.0g |
EUR 138 |
|
Description: CAS# [78578-28-6] |
Aminomethyl resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1005.0025 |
Bachem |
25.0g |
EUR 370.8 |
|
Description: CAS# [78578-28-6] |
Aminomethyl resin (200-400 mesh, 0.80-1.20 mmol/g) |
|
D-1005.0100 |
Bachem |
100.0g |
EUR 1009.2 |
|
Description: CAS# [78578-28-6] |
 Quantifoil R 1.2/1.3; Nickel 400 Mesh 100/pk |
|
M-CEM-Q2100NR2.5 |
MiTeGen |
100 GRIDS |
EUR 812 |
|
Description: Quantifoil R 1.2/1.3; Nickel 400 Mesh 100/pk |
 Quantifoil R 3/3; Copper 400 Mesh 100/pk |
|
M-CEM-Q3100CR3 |
MiTeGen |
100 GRIDS |
EUR 718 |
|
Description: Quantifoil R 3/3; Copper 400 Mesh 100/pk |
 Quantifoil R 1/2 ; Nickel 400 Mesh 100/pk |
|
M-CEM-Q4100CR-12 |
MiTeGen |
100 GRIDS |
EUR 718 |
|
Description: Quantifoil R 1/2 ; Nickel 400 Mesh 100/pk |
 Quantifoil R 2/4 ; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR-4 |
MiTeGen |
- |
EUR 700 |
|
Description: Quantifoil R 2/4 ; Copper 400 Mesh 100/pk |
 Quantifoil R 2/1 ; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR1 |
MiTeGen |
100 GRIDS |
EUR 710 |
|
Description: Quantifoil R 2/1 ; Copper 400 Mesh 100/pk |
 Quantifoil R 10/10 ; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR1010 |
MiTeGen |
100 GRIDS |
EUR 895 |
|
Description: Quantifoil R 10/10 ; Copper 400 Mesh 100/pk |
 Quantifoil R 10/20; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR1020 |
MiTeGen |
100 GRIDS |
EUR 895 |
|
Description: Quantifoil R 10/20; Copper 400 Mesh 100/pk |
 Quantifoil R 10/5; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR105 |
MiTeGen |
100 GRIDS |
EUR 895 |
|
Description: Quantifoil R 10/5; Copper 400 Mesh 100/pk |
 Quantifoil R 17/5; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR175 |
MiTeGen |
100 GRIDS |
EUR 895 |
|
Description: Quantifoil R 17/5; Copper 400 Mesh 100/pk |
 Quantifoil R 2/2 Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR2 |
MiTeGen |
100 GRIDS |
EUR 650 |
|
Description: Quantifoil R 2/2 Copper 400 Mesh 100/pk |
 Quantifoil R 1.2/1.3 ; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR2.5 |
MiTeGen |
100 GRIDS |
EUR 718 |
|
Description: Quantifoil R 1.2/1.3 ; Copper 400 Mesh 100/pk |
 Quantifoil R 1.2/20; Copper 400 Mesh 100/pk |
|
M-CEM-Q4100CR21.2 |
MiTeGen |
100 GRIDS |
EUR 718 |
|
Description: Quantifoil R 1.2/20; Copper 400 Mesh 100/pk |
Mechanical tests for samples of multi-uhmwpe cylinder shapes, made of porous uhmwpe as a trabecular layer and armored layer (cortical layer) consisting of bulk films and UHMWPE, shows an increase in the mechanical properties of all types of glue, as a result of the existence of the UHMWPE film and Increased number of layers. The strength of the maximum press yield and modulus value of the press for the armored layer (bulk and six layers of UHMWPE film using glue based on the Tiol-ENE reaction) is 44.1 MPa (a 1730 mpa increase (increasing 36%), compared to one layer uhmwpe steel Joint reconstruction.
